Drug Elimination

Choose the correct answer for each question.

1 First order elimination is Constant rate per time Contant amount per time Variable rate per time None of the above 2 Half-life is an expression describing Apparent volume of distribution. How quickly a drug is eliminated. Kel x 0.693 Kel / 0.693 3 If the CL of a drug is increased without any affect on Vd, the t 1/2 will: Increase Decrease No effect Invalid assumption 4 If the SDC of a drug falls from 4 to 2 mcg/ml in 3.5 hours, the half-life is: 7 hours 3.5 hours 1.75 hours None of the above 5 Clearance is defined as: Amount of drug cleared per unit time. Volume of blood cleared of drug per unit time. Kel/Vd All of the above