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After selecting a drug model you may modify any of the displayed model parameters (+/- 25% of default parameters):
Vd = DW x Vd L/kg (x CF)
Kel (or CL) = Nonrenal + [Renal x CrCl]
Note: default model parameters are changed with the drug model editor.
Please note that prospective pediatric dosing is weight-based instead of kinetic based, because of the inaccuracy of pediatric creatinine clearance methods.
EI dosing is enabled if:
Retrieve previous analysis
If there is a previous serum level analysis on record for this patient, the Retrieve button will be enabled.
Ideal dose calculation
Click the Calculate button to display the Kel, Vd, and the ideal dosing regimen for the patient and model selected.
You then enter a practical dose and interval. The program will calculate and display an estimated steady-state peak and trough level.
To view the dose in mg/kg, hover the mouse pointer over the dose input box.
After a dose and interval are entered, the Print and View Graph functions are enabled.
If you wish to have a serum level graph printed on your dosing consult, click the View Graph icon then click Save Graph.
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