If a pre-steady-state condition (based on the population model) is detected, two options for analysis are available:
| • | Assume steady state |
| • | Use pre-steady-state method |
To help your decision the dialog displays the percentage of model steady-state. For example, if the regimen is close to 90%, then you may choose to assume steady-state.
Analysis of serum levels prior to steady-state uses a Bayesian methodology. In order to accurately assess pre-steady-state data, the serum level at the start of the current regimen must be known.
| • | Enter 0 (zero) if the patient had no drug on-board when the current regimen was started. |
| • | If the patient did have drug on-board when the current regimen was started, enter the serum level at the start of the current regimen. |
It is important to note that, regardless of which option is selected, analysis of serum levels drawn prior to steady-state is not as accurate as a steady-state draw
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