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Chloride is the most abundant extracellular anion; however its intracellular concentration is small. It balances out positive charges in the extracellular fluid and by passively following sodium, helps to maintain osmolality. It plays a role in the ability of blood to carry CO2 to the lungs and is important in potassium conservation.
Empiric daily requirement
Adults: As needed to balance acid/base (80 to 100 mEq/day)
Infants/children: As needed to balance acid/base (2 to 4 mEq/kg/day)
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