Vancomycin dosage calculation

Choose the correct answer for each question.

1 The best strategy for dosing vancomycin Aim for a high peak to maximize killing Aim for a low trough to minimize toxicity Maintain trough above MIC Maintain trough below MIC 2 For practical purposes, round vancomycin doses to The nearest 50mg The nearest 10mg The nearest 250mg The nearest 500mg 3 If a 1-compartment model is utilized Give smaller doses more frequently Obtain peak levels 15-30 minutes after administration Give larger doses more freqently Obtain peak levels at least 1-2 hours after administration 4 The main reason vancomycin dosage requirements are so unpredictable Inter-patient variability of Vd Hybrid values are utilized Infusion length varies All of the above 5 In the 2-compartment model The peak drives the dose The trough drives the dose The interval drives the dose None of the above