Vancomycin

Choose the correct answer for each question.

1 The best strategy for dosing vancomycin Continuous infusion Maximize amount Extended interval Maximize concentration 2 Vancomycin nephrotoxicity is Well documented Related to elevated peak levels Conclusively related to elevated trough levels. None of the above 3 A 1-compartment model for vancomycin Gives the best overall predictive performance. Results in a significant improvement. Requires post-distribution serum samples. Is the least used model. 4 Target peak levels for vancomycin At least 8-10 times the MIC Should remain above the MIC Correlate with efficacy None of the above All of the above 5 During prolonged therapy, what property of vancomycin necessitates close monitoring of SDC's? Inter-patient variability Accumulation Post-antibiotic effect Concentration-independent killing