Aminoglycoside dosage calculations

Choose the correct answer for each question.

1 What model parameter causes the most variability in the aminoglycoside population model? Kel Vd CL Half-life 2 The ideal dose (MD) is computed from Vd Target trough Target peak Both A and C Both A and B 3 What parameter is computed from a Dettli plot of creatinine clearance? Kel Vd CL All of the above 4 The ideal dosing interval (tau) is computed from Vd Target peak Target trough Both A and C Both B and C 5 Sawchuk and Zaske's method utilizes peak and trough levels to compute: Kel Vd Ideal dose Both B & C Both B & A