Aminoglycosides

Choose the correct answer for each question.

1 The best strategy for dosing aminoglycosides Continuous infusion Smaller doses, more frequently Larger doses, less frequently Smaller doses, less frequently 2 Aminoglycoside nephrotoxicity is most closely associated with Temporarily elevated peak levels Temporarily elevated trough levels Sustained elevated trough levels All of the above 3 Extended-interval (or "once-daily") aminoglycoside dosing is NOT appropriate in: The elderly Patients with significant renal impairment Patients with endocarditis All of the above 4 Which of the following is critical to therapeutic success of aminoglycosides: Duration of therapy Achieving therapeutic serum levels Elevated trough levels All of the above 5 In practical terms, PAE means Trough levels must stay 8 times above the MIC Peak levels must stay 8 times above the MIC Trough levels can drop below the MIC Peak levels can drop below the MIC 6 What is associated with the greatest source of error in TDM: SDC drawn before steady-state. Lab assay error Inaccurate recording of administration times Pharmacy dispensing error