Aminoglycosides
Choose the correct answer for each question.
 

1The best strategy for dosing aminoglycosides
Continuous infusion
Smaller doses, more frequently
Larger doses, less frequently
Smaller doses, less frequently

2Aminoglycoside nephrotoxicity is most closely associated with
Temporarily elevated peak levels
Temporarily elevated trough levels
Sustained elevated trough levels
All of the above

3Extended-interval (or "once-daily") aminoglycoside dosing is NOT appropriate in:
The elderly
Patients with significant renal impairment
Patients with endocarditis
All of the above

4Which of the following is critical to therapeutic success of aminoglycosides:
Duration of therapy
Achieving therapeutic serum levels
Elevated trough levels
All of the above

5In practical terms, PAE means
Trough levels must stay 8 times above the MIC
Peak levels must stay 8 times above the MIC
Trough levels can drop below the MIC
Peak levels can drop below the MIC

6What is associated with the greatest source of error in TDM:
SDC drawn before steady-state.
Lab assay error
Inaccurate recording of administration times
Pharmacy dispensing error