KinPlot© is a tool for learning pharmacokinetic concepts by visualizing the effects that various parameters have on serum levels, leading to a better understanding of drug regimen design.

## Overview

This web application requires a modern web browser which supports Javascript and HTML5. Examples include: Chrome, Firefox, Internet Explorer 10, or Safari.

All inputs are required:

- Half-life in hours
- Volume of distribution (Vd) in liters.
- Dose in mg.
- Dosing Interval in hours.
- Infusion length in minutes.
- Starting serum level in mcg/ml

## Graphing

After entering all model inputs, click the Graph button to view a serum level plot. The plot shows the approach to steady-state for a 1-compartment open model.

- Model inputs are displayed in the grid.
- To simulate a continuous infusion
- Enter the dose as mg per 60 minutes
- Enter an Interval of 1 hour
- Enter an Infusion length of 60 minutes

- To simulate an IV bolus
- Enter an Infusion length of 6 minutes

## Buttons

Three buttons appear along the top of the page.

**Home**- Return to the main screen**Help**- Read the help document**Contact**- How to contact RxKientics

Two buttons appear along the bottom of the model parameter inputs.

**Graph**- Create a serum level graph based on the current inputs**Clear**- Clear the current graph series

## Graph data grid

The color-coded grid along the bottom of the graph lists all inputs for the current series of graphs.

## Equations

To calculate serum levels for a one compartment intermittent infusion:

Peak = [Dose / (t*inf* x Vd x Kel)] x [(1 - *e*^{-Kel x tinf}) / (1 - *e*^{-Kel x tau})]

Trough = Peak x *e*^{-Kel x (tau-tinf)}

__where__

Dose = chosen dose in mg

tau = chosen dosage interval in hours

t*inf* = infusion time in hours

Vd = volume of distribution in liters

Kel = elimination rate constant = 0.693/half-life

## Feedback

Please, your feedback and suggestions for improving the program are welcome and encouraged!

Please email your comments and suggestions to ricktharp at rxkinetics.com.

Thank you.