How to enter a drug model

Ampicillin 1-compartment model

1. Start the Edit drug model function by clicking File then Edit drug models from the menu bar.

2. To add a new model, click the add icon ( + ) on the database navigation bar.

3. Enter the following data in the appropriate fields. You may, of course, use numbers for Vd and Kel which are better suited for your patients.

   Field	Data	Notes
   Drug name	Ampicillin	Must be a unique name
   Vd (L/kg)	0.26	Volume of distribution (L/kg)
   CF for Vd	0.4	Vd correction for obesity
   Renal Kel	.0064	From the Kel equation Kel = Nonrenal + (CrCl x Renal)
   Nonrenal Kel	.058	From the Kel equation Kel = Nonrenal + (CrCl x Renal)
   Target peak	50	Target peak level
   Peak predict time	0	Time, after the end of the infusion, that you will be targeting your peak. This is usually set to zero, unless you are modeling a drug with a long distribution time, e.g., vancomycin.
   Target trough	5	Target trough level
   Infusion time	30	Length of infusion in minutes
   EI Dose	0	Dose for extended interval ("once-a-day") AG dosing. Enter zero to suppress.
   Pediatric dose (mg/kg)	50	Applies if age is 8 days to 11 years
   Pediatric Interval (hours)	6
   Neonatal dose (mg/kg)	50	Applies if age is 1 to 7 days
   Neonatal interval (hours)	12
   Permit serum level analysis	(leave unchecked)	You would check this if your drug model has a routine serum level assay, e.g., AG's and vanco.

   Click here to view a screen shot of the editing screen.

4. To post changes, click the post button (check mark) on the databar.

5. Click the close button to save the drug model database and return to the main APK© window.

For more information on building models "from scratch", see this tutorial:

Click here to view the model building tutorial.

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