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1. Monitoring parameters:
Obtain levels 24 hours after initiating therapy, at steady state (approximately four half-lives), and every 2 to 3 days. For extended interval dosing method, obtain mid-interval drug level 6 to 14 hours after the initial dose and repeat drug level 1-2 times weekly. Patients with fluid shifts may need more frequent monitoring.
Measure every two days, or every day in unstable renal function.
2. Therapeutic serum concentrations (mcg/ml)
Serious infection: 6-8
Life-Threatening infection: 8-10
Serious infection: 0.5-1.5
Life-Threatening infection: 1- <2
Serious infection: 20-25
Life-Threatening infection: 25-30
Serious infection: 1-4
Life-Threatening infection: 4-8
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