Click this tab to perform serum level analysis. Data entry fields have a white background, calculated fields which cannot be edited have a yellow background.

A cue card displays on-screen instructions for each data entry field. Dates must be entered in MM/dd/yyyy format. If you experience problems entering dates, see the Getting Started section of the help file for more information. Times must be entered in 24 hour military format, without colons, acceptable range is 0000 to 2359.

After serum level data entry is completed, click the Calculate button. The program then calculates an "ideal" dose and interval.

• For aminoglycosides, if only one serum level is entered, a Bayesian algorithm is utilized, if more than one serum level is entered, the program gives the user the option to choose either a traditional or a Bayesian approach.
• For vancomycin, a 2-compartment Bayesian algorithm is utilized.
• For digoxin, a linear methodology is utilized.
• For theophylline, if only one serum level is entered, a linear methodology is utilized.If two serum levels are entered, and the data meets the criteria, the Chiou method of non-steady-state analysis is utilized.

For 1 and 2 compartment drugs administered by intermittent infusion there are five options for analyzing serum level data, the program will automatically choose which method to utilize, depending on your data entry:

• Use of the Bayesian algorithm permits a single steady-state trough level to be analyzed. (Key = 1)
• The more traditional steady-state peak and trough level analysis, drawn before and after a sample dose, is supported. (Key = 1, 4)
• First dose, non-steady-state analysis where 2 to 3 levels are drawn after the loading dose is supported. (Key = 4, 5, 6)
• The 3-point method is also supported, where a steady-state trough before the dose, a peak, and a mid-interval level after the peak are drawn. If this option is chosen, linear regression is used to determine the line of best fit. (Key = 1, 4, 5)
• Finally, for aminoglycosides, if the extended interval method is chosen, a random level drawn 6-14 hours after the end of the infusion is analyzed. (Key = 5)

The following key may help in understanding the serum level data the program is asking for:

The user enters a practical dose and interval and the program calculates the projected steady state peak and trough levels.

Click below to jump to a drug reference:

• Aminoglycosides
• Digoxin
• Heparin
• Renally excreted drugs
• Theophylline
• Vancomycin

---

---

[ Return to Home ] [ About Kinetics© for Windows ]