The edit drug models function is accessed from the drop-down menu tree or via the keyboard shortcut, Ctl+E. This one of the most powerful features of Kinetics©, you may:
With this feature you could consider the Kinetics© program a "Swiss army knife" for pharmacokinetics, a tool you can use to dose any drug. Because this function is so powerful, it is password protected. The program ships without a password, the first time you access the edit drug models function it will ask for a password and then ask you to confirm it before saving it. Please note that the password is case-sensitive. Thereafter, this will be the password required to access the edit drug models function, so choose one that you can easily remember. lf you should lose or forget your password, contact the author for help in recovering it.
The drug models database is accessed in a manner similar to the patient database. Understanding how to use the database navigation bar is the key. While the program is running, hold the mouse pointer over a button and a tool tip pops up to tell you its function.
There are four command buttons along the bottom of the drug model window. Prior to saving the current model, you can undo any changes you have made by clicking the Undo button. To delete a drug model, click on the Delete button.
Caution: once a model is deleted it cannot be recovered, even with the Undo button! Clicking the exit button will save the drug model database and return you back to the main Kinetics screen.The drug database cannot have two drug models with exactly the same name. If you try to add two drugs with the same name you will get an error message. The workaround is to make each model name unique, for example if you wanted to add a gentamicin model for burn patients, name it "Gentamicin burn".
There are seven model types:
| 1 | One-compartment model |
| 2 | One-compartment model or dosing table |
| 3 | Two-compartment model |
| 4 | Two-compartment model or dosing table |
| 5 | Dosing table |
| 6 | Digoxin |
| 7 | Theophylline |
Some fields are not applicable to all model types, fields with a grey background are not applicable to the current model type. The following table describes the fields that are associated with each drug model:
| Field | Description | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
| Drug name | Name of model (must be a unique name) | x | x | x | x | x | x | x |
| Vd peripheral | Vd peripheral compartment (lL/kg of dosing weight | x | x | x | x | x | x | |
| Age correction for elderly | Vd correction for elderly patients (age > 65 years) | x | x | x | x | |||
| Wt correction for obesity | Use to calculate dosing weight: DW = LBW + [CF x (ABW-LBW)] | x | x | x | x | x | ||
| Target PK | Target peak level, if applicable | x | x | x | x | |||
| Target TR | Target trough level | x | x | x | x | x | x | |
| Infusion | Default time of infusion (minutes) | x | x | x | x | x | x | |
| Vd central | Vd central compartment (L/kg) | x | x | |||||
| Renal | Renal portion of CL/Kel equation: CL/Kel = Nonrenal + (CrCl x Renal) | x | x | x | x | x | x | |
| Nonrenal | Nonrenal portion of CL/Kel equation: CL/Kel = Nonrenal + (CrCl x Renal) | x | x | x | x | x | x | |
| k12 | Distribution constant central to periph | x | x | |||||
| k21 | Distribution constant periph to central | x | x | |||||
| Max dose | Max recommended daily dose (mg/kg/day) | x | x | x | x | x | x | |
| QD dose | mg/kg dose for extended interval dosing of aminoglycosides | x | ||||||
| MIC | Default minimum inhibitory concentration | x | x | x | x | |||
| SD Vd | Population Vd, standard deviation (needed for Bayesian analysis) | x | x | |||||
| SD Kel/Cl | Population Kel/Cl, standard deviation (needed for Bayesian analysis) | x | x | |||||
| SD CP1 | Serum level standard deviation* (needed for Bayesian analysis) | x | x | |||||
| SD CP2 | Serum level standard deviation* (needed for Bayesian analysis) | x | x | |||||
| SD CP3 | Serum level standard deviation* (needed for Bayesian analysis) | x | x | |||||
| SD CP fixed | Serum level standard deviation* (needed for Bayesian analysis) | x | x | |||||
| Dosing table | Dosing table | x | x | x | ||||
| Care plan | Pharmaceutical care plan | x | x | x | x |
*Used to calculate serum assay error with a second order polynomial equation. See Bayesian principles section for more detailed information.